Semaglutide (Wegovy)

Semaglutide has become one of the most discussed treatments for weight management in recent years. Here's what you need to know about this medication.

What's It For?

Wegovy is prescribed for chronic weight management in adults who are either:

• Obese (BMI of 30 or higher), or
• Overweight (BMI of 27 or higher) with at least one weight-related condition like type 2 diabetes, high blood pressure, or high cholesterol (dyslipidemia)

It's important to understand that Wegovy is prescribed alongside lifestyle modifications, including a reduced-calorie diet and increased physical activity. The medication is designed to complement these changes, not replace them.

How It Works

Wegovy belongs to a medication class called GLP-1 receptor agonists. Like Ozempic (which contains the same active ingredient but is approved for diabetes management), Wegovy helps regulate appetite and energy balance.

The medication works in two primary ways:

1. It mimics a natural hormone that targets areas of your brain responsible for appetite control, helping reduce hunger signals and calorie intake.
2. It slows down how quickly your stomach empties, which promotes a feeling of fullness after eating.

These combined effects help many people consume fewer calories without feeling constantly hungry.

How to Take It

Wegovy is administered as a once-weekly injectable medication. The injection is given subcutaneously (under the skin) in the abdomen, thigh, or upper arm, ideally on the same day each week for consistency.

Your doctor will start you on a lower dose and gradually increase it over 16-20 weeks:

• Starting dose: 0.25 mg weekly
• Gradually increased over several months
• Maintenance dose: 2.4 mg weekly

This gradual approach helps minimize side effects as your body adjusts to the medication.

Side Effects: The Real Deal

Like all medications, Wegovy can cause side effects. Being aware of these potential effects is important for making informed decisions.

Common Side Effects

The most frequently reported side effects affect the digestive system:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Fatigue

These side effects often improve as your body adjusts to the medication.

Serious Side Effects

While less common, more serious side effects can occur:

• Risk of pancreatitis (inflammation of the pancreas)
• Gallbladder problems, including gallstones
• Rare thyroid tumors (primarily in people with a family history)
• Hypoglycemia (low blood sugar), especially if you're taking other diabetes medications

Contact your healthcare provider immediately if you experience severe abdominal pain, persistent severe nausea or vomiting, or difficulty swallowing.

Making It Work For You

To get the most benefit from Wegovy while minimizing risks, consider these guidelines:

Medical History

Be forthcoming with your doctor about your medical history, especially if you have any history of thyroid cancer, pancreatitis, gallstones, or kidney disease.

Lifestyle Integration

Remember that Wegovy works best as part of a comprehensive approach to weight management. The medication can help control your appetite, but combining it with nutritious, portion-controlled meals and regular physical activity will give you the best results.

Consistency Matters

Take your weekly dose on the same day each week. If you miss a dose and it's been less than 5 days, take it as soon as possible. If more than 5 days have passed, skip the missed dose and continue with your usual schedule.

Regular Monitoring

Keep all follow-up appointments with your healthcare provider. Regular check-ins help track your progress and address any potential issues early.

Medication Interactions

Inform your doctor about all medications, supplements, and herbs you're taking, as well as your alcohol consumption habits. Some combinations might increase the risk of side effects or reduce Wegovy's effectiveness.

Bottom Line

Wegovy represents an important addition to weight management options, particularly for those who have struggled with traditional approaches. While it's not appropriate for everyone, many patients have found it helpful in achieving meaningful weight loss when combined with healthy lifestyle changes.

As with any medical treatment, the decision to use Wegovy should be made in partnership with your healthcare provider, taking into account your individual health profile, goals, and circumstances.